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Abstract

Background

Recurrent and spontaneous seizures are a symptom of the epilepsy. It affects up to 65 million individuals globally, with lower-income nations accounting for 80% of cases. Since medicinal plants have special therapeutic qualities, they are frequently used to manage and cure epilepsy and convulsions. Because they have fewer side effects and stronger therapeutic results, medicinal plants are becoming more and more popular worldwide as a result of increased research and clinical use. The pharmaceutical industry is now concentrating heavily on the creation of novel plant-based antiepileptic/anticonvulsant drugs

Aims of the study:

Study the role of coriander sativum extraction in the modulation of inflammatory and oxidative parameters in rat model of epilepsy.

Material and methods

Twenty-five adults male Wistar albino rats, approximately 12 weeks of age, were split into 5 groups at random, each group consist of 5 rats. The 1st control group received (IP) normal saline, the 2nd group is the epilepsy induction group (each rat received (IP) PTZ 40 mg/kg every 48 hours), and the 3rd group received 200 mg/kg of coriander orally by gavage, and 40 mg/kg of PTZ was subsequently administered intraperitoneally (IP) every 48 hours for seizure induction. The 4th group received 200 mg/kg of levetiracetam intraperitoneally (i.p.), followed by 40 mg/kg of PTZ administered intraperitoneally (i.p.) every 48 hours to induce seizure. Brain tissue was collected and homogenized. The samples were then saved in Eppendorf tubes and centrifuged for 600 seconds at 14,000 x g. The supernatant was carefully collected and saved in a freezer at -20℃ and then thawed at 2-8℃ for a biochemical test for evaluation of inflammatory and oxidant parameters by ELISA test.

Results

There was a significant P0.05) between the coriander + PTZ and levetiracetam + PTZ groups. There was a highly significant (P0.05) in the activity of SOD between the coriander-only group and the coriander+ PTZ group. About the behavioral evaluation coriander exhibit highly significant reduction in both severity and duration of the seizure when compare to PTZ group.

Conclusion

Coriander extract showed the ability to reduce the proinflammatory cytokine TNF-α in epilepsy induced in a rat model at the same time it can increase the level of the anti-inflammatory cytokine IL-10. Coriander sativum extract exhibits antioxidant activity via MDA modulation and elevated levels of antioxidant SOD. And it has the ability to reduce the intensity and duration of the seizure.

References

[1] Bertocchi I, Cambiaghi M, Hasan MT. Advances toward precision therapeutics for developmental and epileptic en cephalopathies. Front Neurosci 2023;(17):1140679.

[2] Yang W, Cui H, Wang H, Wang Z, Yan C, Cheng W. A review of the pathogenesis of epilepsy based on the microbiota-gut- brain-axis theory. Front Mol Neurosci 2024;(7).

[3] Yin Y, Nurulumi A, Makmor-Bakry A. Pathogenesis of ep ilepsy: challenges in animal models. Iran J Basic Med Sci 2013;(16):1119—32.

[4] Mukhara D, Oh U, Neigh GN. Handbook of clinical neurology, vol. 175. Amsterdam, The Netherlands: Elsevier; 2020. p. 235—59.

[5] Prachayasittikul V, Prachayasittikul S, Ruchirawat S. Cori ander (Coriandrum sativum): a promising functional food toward the well-being. Food Res Int 2018;105(3):305—23.

[6] Liu W, Ge T, PanZ LengY, Lv J, Bingjin L. Provincial key laboratory on molecular and chemical genetic. Oncotarget 2017 Apr 3;8(29):48385—97.

[7] Mahendra P, Bisht S. Coriandrum sativum: a daily use spice with great medicinal effect. Pharmacogn J 2021;21(3):84—8.

[8] Ashraf K. Synthesis, characterization, and antibacterial po tential of silver nanoparticles synthesized from Coriandrum sativum L. J Infect Public Health 2019;12(2):275—81.

[9] Alvi AM, Shah FA, Muhammad AJ, Feng J, Li S. 1,3,4, oxa diazole compound A3 provides robust protection against MA'AEN JOURNAL FOR MEDICAL SCIENCES 2025;4:175—183 183 PTZ-induced neuroinflammation and oxidative stress by regulating Nrf2-Pathway. J Inflamm Res 2021;14(2021): 7393—409.

[10] Hosseini M, Boskabady M, khazdair M. Neuroprotective effects of Coriandrum sativum and its constituent, linalool: a review. Avicenna J Phytomed 2021;11(5):436—50.

[11] Ignacio-Mejía I, Contreras-García I, Julieta O, Pedraza- Chaverri, Romo-Mancillas Antonio, G omez-Manzo Saúl, et al. Evaluation of the antioxidant activity of levetiracetam in a temporal lobe epilepsy model. Biomedicines 2023;11(3): 848.

[12] Alvi AM, Shah FA, Muhammad AJ, Feng J, Li S. 1,3,4, oxa diazole compound A3 provides robust protection against PTZ-induced neuroinflammation and oxidative stress by regulating Nrf2-Pathway. J Inflamm Res 2021 Dec 29;14: 7393—409.

[13] Chen XM, Zhang S, Gao SQ, Xu M. Interleukin-6 in epilepsy and its neuropsychiatric comorbidities: how to bridge the gap. World J Psychiatr 2025;15(1):100297.

[14] Scandar Samiri, Zadra Claudia, Marcotullio Maria Carla. Coriander (Coriandrum sativum) polyphenols and their nutraceutical value against obesity and metabolic syn drome. Molecules 2023;9(1):4187.

[15] Staley K. Molecular mechanisms of epilepsy. Nat Neurosci 2015;(18):367—72.

16] Yi S, Ma Jiangjun, Li Dongfang, Li Pinggan, Zhou Xiaolin, Li Yu, et al. Interleukin-10 inhibits interleukin-1β produc tion and inflammasome activation of microglia in epileptic seizures. J Neuroinflammation 2019;(28):16—66.

[17] Li Wenjun, Wu Jinze, Zeng Yini, Wen Zheng. Neuroinflammation in epileptogenesis: from pathophysi ology to therapeutic strategies. Front Immunol 2023;(14): 220—36.

[18] Michev A, Orsini O, Santi V, Bassanese F, Veraldi D, Brambilla I, et al. An overview of the role of tumor necrosis factor-alpha in epileptogenesis and its terapeutic implica tions. Acta Biomed 2021;4(92):e2021418.

[19] Kern C, Gombert C, Roso A, Garcia C. Soothing effect of virgin coriander seed oil on sensitive skin. OCL 2020;(27):49.

[20] Trisia A, Hidayah N, Syahadatina N, Hartoyo E, Himawan Indra Widjaja. Role of neurogenesis and oxidative stress in epilepsy (Study on plasma brain derived neuro trophic factor and Malondialdehyde level. Macedonian J Med Sci 2023;11(B):46—53.

[21] de Melo A, Ferreira Freire V, Diogo I, Santos H, Augusto L, de Carvalho L. Antioxidant therapy reduces oxidative stress, restores Na,K-ATPase function and induces neuroprotection in rodent models of seizure and epilepsy: a systematic review and meta-analysis. Antioxidants 2023;12(7):1397.

[22] Karami R, Hosseini M, Mohammadpour T, Ghorbani A, Sadeghnia H, Rakhshandeh H, et al. Effects of hydro alcoholic extract of Coriandrum sativum on oxidative damage in pentylenetetrazole-induced seizures in rats. Iran J Neurol 2015;14(2):59—66.

[23] Delphine Ji, Mylvag Anam S, Chander P, Tarnopolsky M, Murphy K, Carlen Peter. Mitochondria and oxidative stress in epilepsy: advances in antioxidant therapy. Front Phar macol Sec Neuropharmacol 2025;3(15):224.

[24] Yilgor A, Demir C. Determination of oxidative stress level and some antioxidant activities in refractory epilepsy pa tients. Sci Rep 2024;6688(14):25—46.

[25] Pourzaki M, Homayoun M, Sadeghi S, Seghatoleslam M, Hosseini M, Bideskan A. Preventive effect of Coriandrum sativum on neuronal damages in pentylentetrazole-induced seizure in rats. Avicenna J Phytomed 2017 Mar-Apr;7(2): 116—28

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