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Abstract

The aim of the current study was to formulate and evaluatedompridone nanoparticles and loaded in oral fast dissolve film, for enhance the solubility of poor water soluble dompridone by nanoparticles and fasten the action by prepared as oral thin film and also to improve patient compliance. Domperidone is the recommended medication for nausea and vomiting brought on by viral infections, chemotherapy, migraines, and food poisoning.Domperidonenanoparticles were made using two type of polymers (hydroxypropyl methylcellulose HPMC-K15 and methylcellulose MC-A4C) in a range of ratios (1:1, 1:2, and 1:3) drug:polymer ratio by solvent antisolvent technique. In nanoparticle formulation, HPMC-K15 and MC-A4C were selected due to their advantageous characteristics: they are water-soluble, form robust films, are biologically compatible, and have a proven history in pharmaceutical applications.The preparedformula undergoes to characterization for particle size, PDI, FESEM and x-ray diffraction. The results obtain show all formulas within nano size range and monodisperse. The X-ray powder diffraction examination showed that the dompridone had changed from a crystalline to amorphous state. Following that, the optimum nanoparticles formulawas used to prepare the oral film using the technique of solvent casting with HPMC E15 acting as a film forming agent and glycerin as a stabilizer. The prepared oral film, appear as a white, opaque,soft thin film with drug content 98.85±1.13%, and a good folding endurance. Invitro release of drug show, the cumulative proportion of dopamine released from the film containing the nanoparticles was 43%, while only 21% for film consist of pure dompridone, at two minute.

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