Abstract
Background: Since seizures may be the only sign of central nervous system disorder, their recognition is important. Seizures are not only more frequent in neonatal period but they are also more difficult to be diagnosed because of subtle nature of neonatal convulsion.
Objective: Study the causes and treatment response on neonatal convulsion.
Methods: This prospective descriptive study applied on 65 cases admitted to child's central khalis hospital. Patients were collected according to gestational age, sex, date of convulsion, cause of convulsion. Basal line investigations done for all these patients which include (complete blood picture, Serum electrolyte, random blood sugar, and lumbar puncture). while U/S of brain and CT. scan done according to case.
Results: Most cases of neonatal convulsion presented in the 1-4 days of life which constitutes 63% and male to female ratio was 3:2 out of 65 cases with convulsion (86% of them were term. Concerning the etiology hypoxic ischemic encephalopathy (HIE) constitutes (53.8%) of the select cases. Meningitis form (13.8%). Hypocalcemia presented in (10.8%) and hypo glycaemia was seen in (7.7%) of studied cases. kernicterus, intracranial hemorrhages, cerebral abnormally form (1.5%) of cases for each one of them. Undiagnosed cases constitute (9.2%), Nine cases were died 13.85% the meningitis was the most common cause of death which seen in 55.6%followed by HIE which seen in 8.6%.
Conclusion: Hypoxic ischemic encephalopathy was the most common causes of convulsion in neonate while the most common causes of death was meningitis.
Recommended Citation
Mohammed, Shaimma Jassim
(2025)
"Causes and Treatment Responses for Neonatal Convulsions,"
Maaen Journal for Medical Sciences: Vol. 4
:
Iss.
1
, Article 3.
Available at: https://doi.org/10.55810/2789-9136.1067
References
[1] Goetz Ch G, Pappert EJ. Neonatal seizures inNancyfoldvary, Elaine wyllie. Textbook of clinical neurology. Philadelphia: Saunders; 1999. p. 1074e6.
[2] Haslam RH. Neonatal seizures. In: Kliegmen RM, re Behrman, Jenson HB, editors. et al Nelson textbook of pediatric. 18th edition. Philadelphia. 591 2007. p. 2471e3.
[3] Holmes Gregory L, Khazipov Roustem, Ben-Ari Yehezkiel. New concept in neonatal seizures. Neuroreport 2002;13: A3eAg.
[4] Rennie JM, Seizures in Janet M Rennie. Roberton's textbook of neonatology. 4th ed. Elsevier; 2005. p. 1105e17.
[5] Coulter DL, Allen RJ. Benign neonatal sleep myoclonus Archieves of Neurology, vol. 39; 1990. p. 191e2.
[6] Parker Steven, Zuckerman Barry, Howard Bauchner, Frank Deborah, Vinci Robert, Howard Cabral. Jitteriness in full term neonates: prevelance and correlates. Pediatrics 1990;85:17e23
. [7] Tohier C, Roze JC, David A, Veccierini MF, Renaud P, Mouzard A. Hyperkplexia or stiff baby syndrome. Arch Dis Childhood 1991;66:460e1.
[8] Stewart WA, Wood EP, Gorden KE. Successful treatment of severs infantile hyperekplexia with low dose of clobazam. J Child Neurol 2002;17:154e6.
[9] Shiang Rita, Ryan Stephen G, Zhu Ya-Zhen, Fielder Thomas J, Allen Richard J, Fryer Alan, et al. Mutational analysis of familial and sporadic hyperekplexia. Ann Neurol 1995;38: 85e91.
[10] Kohelet D, Shochat R, Lusky A, Brain R. Risk factors for neonatal seizures in very low birth weight infant: population-based survey. J Child Neurol 2004;19:1e9.
[11] Herzlinger RA, kandall SR, Vaugham HG. Neonatal seizurs associated with narcotic withdrawal. J Pediatr 1992;91:638e41.
[12] French JP, Nocera M. Drug with drawal symptoms in children after continous infusion of fentanyl. J Pediatr Nurs 1994; 9:107e13.
[13] Haslam HR, Seizures N, Kleigman RM, Behraman RE, Jenson HB. In: Nelson textbook of pediatrics 17 edition, Philadelphia; 2021. 584 2021. p. 2005e7. 28 MA'AEN JOURNAL FOR MEDICAL SCIENCES 2025;4:23e29
[14] Nabbout R, Soufflet C, Plouin P. Pyridoxine dependent epilepsy: a suggestive electroclinical pattern. Arch Dis Childhood 2021;81:F125e9. 2022.
[15] Baxter P. Pyridoxine-dependent and pyridoxine-responsive seizures. Dev Med Child Neurol 2001;43:416e20. 2021.
[16] McIntosh N, Helms PJ, Smyth RL, Logan S. Neonatal neurology farfar and Arneils B textbook of pediatrics. 7th ed. Elsevier; 2008. p. 304e9. Newyork oxford philadelphia.
[17] Gold berg HJ. Fifth day fits-an acute zinc deficiency syndrome. Arch Dis Childhood 1985;57:633e5.
[18] HayWW, Hayward AR, LevinMJ. Neurological problem in the new born infant. Current Ped Diagnosis Treatment 2020-2021: 731-732. 16 edition the Mecgraw-Hill companies, Inc.
[19] Nilson text book of pediatrics edition 21. Elsevier; 2020.
[20] Gomella TL, Cunning ham MD, Eyal FG, Karin E. Zenk. Neonatology management of procedures on call problem. Disease & drug. 5th ed. Mcgrual-hill companics; 2004. p. 310e3. 2020.
[21] Boylan GB, Rennie JM, Chorley G, Pressler RM, Fox GF, Farrer K, et al. The second line anticonvulsant and treatment of neonatal seizures: a video EEG. Arch Dis Child 2022;62: 486e8.
[22] Painter Michael J, Scher Mark S, Stein Aryeh D, Armatti Stacey, Wang Zhiming, Gardiner Joseph C, et al. Phenobarbital compared with phenytoin for treatment of neonatal seizures. N Engl J Med 1999;341:485e9.
[23] Rennie JM, Boylan G. Neonatal seizures and their treatment curr opin neural, vol. 16; 2003. p. 177e81.
[24] Gal Peter, Oles Karen S, Gilman Jamie T, Weaver Richard. Valproic acid efficacy toxicity and pharmacy kinetics in neonate with intractable seizures. Neurology 1988;38:467e71.
[25] Al cover-Bioch E, campistol J, Iriondo-sanz M. Neonatal seizures, our experience. Rev neural 2004;38(9):808e12.
[26] Eghbatian F, Monsef A, Taghdir MM. Neonatal seizures : etiolagy and frequency. Iran J Child Neurol 2008;2(2):39e42.
[27] Tasksanda AM, Vilgekar K, Jain M. Clinic e biochemical profile of neonatal seizures pediatric on call. 2005.
[28] G.Ronen , S penney , W.Andrew:The epidemiology of clinical neonatal seizures in new found land: a population study . J Pediatr, vol 131(1):71-75.
[29] Volpe JJ, editor. Neonatal seizures, neurology of new born 4thed. Philadelphia W.B. Saunders; 2001. p. 178e216.
[30] Eriksson M.Zette Rstromr: Neonatal convulsions incidence and causes in Stockholm area actapediatrica.
[31] Yassir SAbed. Clinical study of neonatal seizures in AlKhansaah teaching hospital for pediatrics in Mosul. A thesis submitted to Iraqi commission for medical specialization of pediatric. 2005. p22
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