Ibuprofen is a well-known Non-steroidal anti-inflammatory drugs (NSAID) that has historically been used for its analgesic, anti-inflammatory, and antipyretic effects. It is used as an over-the-counter pain reliever for conditions like headache, backache, muscle aches, toothaches, fever, and dysmenorrhea. It is used to treat chronic illnesses such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and others for an extended period of time. Due to its great efficacy compared to acetaminophen and relative safety compared to aspirin, it is also frequently used in juvenile patients to treat acute pain and fever by inhibiting prostaglandins, but they can also lower immunity by reducing the production of cytokines like IL-6. This study aimed to predict the effect of ibuprofen on immune response. A clinical trial study was done by selecting four rats their weight were about 170.58 – 244.42 then will divided in to groups to detect the effect of NSAID on them. The results was show a significant effect P < 0.001 of profin in reducing immune response representing by IL-6 between the two groups.


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