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Abstract

Background: pharmacovigilance is the science and activities that used to detect, evaluate, understand, and prevent drugs' adverse effects and to ensure that medicines are used safely and effectively. Antimicrobials considered as an important curable medicine for diseases; however, irrational medical prescribing may lead to differing types of adverse drug reactions (ADRs) Aim of Study: The study aims to summarize besides analyzing data from the pharmacovigilance center in Basrah concerning antibiotic use-related ADR. Method: This study is a retrospective cohort study of antibiotic used in 2022-2023. The study population consists of patients who received antibiotics during the study period. The outcome of interest is the incidence of antibiotic associated adverse events. Results: Penicillin and third-generation cephalosporin were the most frequent causes of ADRs, and both were account for 29.00% of the reported cases followed by glycopeptide, and vancomycin about 24.00%. The most common clinical manifestations were skin and subcutaneous tissue disorders, occurred in 80 cases (75.00%), after which difficulty in breathing (8.50%) and with remaining (16.00%) miscellaneous symptoms like hypotension, urticaria, headache, and GIT disorders were come. Conclusion: Penicillin and third-generation cephalosporin were the most frequent causes of ADRs, skin manifestations were the most frequently reported adverse events. Inappropriate antibiotic prescriptions were common and associated with increased risks of adverse drug events and higher attributable healthcare expenditure and increase need for education programs for rational use of antibiotics.

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