Beta thalassemia major () is one of the more prevalent hereditary diseases in the globe due to a deficiency of globin chains. It is associated with lipid abnormalities, electrolytes, and oxidative stress that can lead to potentially fatal complications. The current study included 100 patients diagnosed with in an age group of 2-18 years compared to 80 healthy subjects. The current study included evaluating Complete blood count (CBC), iron status, lipid profile, potassium, and magnesium. Also, Oxidative status represented by Superoxide dismutase (SOD), Catalase (CAT), and Nitric oxide (NO) were investigated. The finding of this study included a significant increase of triglycerdes (Tg), very low-density lipoprotin (VLDL), and Potassium levels of the patients with compared to the healthy control group, while a significant decrease in total cholsterol (TC), high-density lipoprotin (HDL), low-density, lipoprotin (LDL), SOD, CAT, NO, and magnesium levels. Moreover, Pearson's correlation coefficient (r) was also found between the oxidative status parameters, Potassium, and magnesium studied for β-thalassemia patients vs ferritin levels that were found a negative correlation with SOD, CAT, NO, and magnesium levels whereas positive correlation with Potassium level. The finding of the current study showed a clinical predictor of dyslipidemia, state of oxidative stress, and high risk each of Hyperkalemia and hypomagnesemia, which portends the use of more efficient treatment protocols to remove excess iron from patients.
Ibrahim, Ahmed jaber and AL–Saeed, Arwa H. M.
"Evaluation of oxidative status, potassium, magnesium, and lipid profile in serum of patients with β-thalassemia major, Thi-Qar, Iraq.,"
Maaen Journal for Medical Sciences: Vol. 2
, Article 3.
Available at: https://doi.org/10.55810/2789-9136.1029
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