Eplerenone is an aldosterone receptor inhibitor utilized for management of hypertension and chronic heart failure. However, it’s low solubility and dissolution-dependent absorption lead to reduced oral bioavailability (The absolute bioavailability of eplerenone is 69%). This study aimed to develop and optimize eplerenone nanosuspension (EPLNS) to enhance its solubility and improve dissolution rate. The nanosuspension (NS) was produced using the solvent anti-solvent precipitation method, and an investigation was conducted to assess the effect of variables such as stabilizer type, stabilizer concentration, and stirring rate on particle size (PS) and polydispersity index (PDI). The results showed that most of the prepared EPLNS formulations exhibited particle sizes in the nanoscale range. The optimized EPLNS formulation (F9), stabilized with tween 80 at an amount of 10 mg under a stirring rate of 1000 rpm, exhibited the minimum particle size (165.5 nm) and an appropriate PDI (0.2199). Moreover, this formulation displayed an enhanced dissolution velocity in phosphate buffer pH 6.8, with 92.5% drug release achieved within 15 minutes. The dissolution rate of the prepared EPLNS exhibited a significant enhancement when compared to that of the pure EPL powder.


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