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Abstract

Backgrounds: Polycystic ovary syndrome is the most common endocrine and reproductive disorder in the reproductive-age women. Among the pathological changes that are responsible for the development of polycystic ovary syndrome (PCOS), hyperinsulinemia due to increased insulin resistance (IR) is common and usually associated with a higher rate of ovulatory dysfunction and sub-fertility. In addition, those women have poor quality oocytes with low fertilization capability and poor quality embryos. So, insulin has a role in the reproductive function and fertility potential of reproductive age women. Conclusion: Females with PCOS usually exhibit an extreme difficulty in achieving either a successful spontaneous or assisted pregnancy. Hyperinsulinemia / insulin resistance and reproductive dysfunction should be well understood as can as possible in order to achieve an effective treatment plan to increase the chance of a successful uncomplicated pregnancy.

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