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Abstract

Conventional dosage forms could not manage release of active substances resulting in reduced bioavailability and side reactions. Being retained in a certain site in the gastrointestinal tract (GIT) could achieve further bioavailability particularly regarding drugs having low gastric absorption and low solubilization or less stability at elevated pH. Therefore, Gastroretentive drug delivery systems (GDDS) are unique approaches with gastric retention and controlling the release rate for maximizing the efficacy. The polymers broadly applied in GDDS are mainly of two sorts, natural and synthetic, according to their nature. Synthetic polymers such as Hydroxypropylmethyl cellulose (HPMC), Eudragit and Ethylcellulose while natural polymers such as natural gums, sodium alginate and Chitosan.

References

  1. Qin C, Wu M, Xu S, Wang X, Shi W, Dong Y, et al. Design and optimization of gastro-floating sustained-release tablet of pregabalin: in vitro and in vivo evaluation. Int J Pharm 2018;545:37e44. https://doi.org/10.1016/j.ijpharm.2018.04.011.
  2. Rahamathulla M, Hani U, Alqahtani A, Gangadharappa HV, Begum Y, Jafar M, et al. 2 Factorial design and optimization of effervescent floating matrix tablet of neratinib. J Pharm Innov 2021;16:528e36. https://doi.org/10.1007/s12247-021-09563-4.
  3. Huh HW, Na YG, Kang HC, Kim M, Han M, Pham TMA, et al. Novel self-floating tablet for enhanced oral bioavailability of metformin based on cellulose. Int J Pharm 2021;592:120113. https://doi.org/10.1016/j.ijpharm.2020.120113.
  4. Alam MD, Hani U, Ibrahim Q, Alhamhoom Y. Development and in vitro evaluation of effervescent floating matrix tablet of neritinib: an anticancer drug. Pak J Pharm Sci 2021;34:1297e303. https://doi.org/10.1007/s12247-021-09563-4.
  5. Tripathi J, Thapa P, Mahaarian R, Jeong HS. Current state and future prespectives on gastroretentive drug delivery systems. Pharmaceutics 2019;11:193. https://doi.org/10.3390/pharmaceutics11040193.
  6. Hsu Y, Kao C, Ho M, Lee S. To control floating drug delivery system in a simulated gastric environment by adjusting the Shell layer formulation. Biomater Res 2021;25:31. https://doi.org/10.1186/s40824-021-00234-6.
  7. Zubedi SS, Mohammed S. Floating tablets and its polymers. J Drug Deliv Therapeut 2018;8:16e24. https://doi.org/10.22270/jddt.v8i5-s.1928.
  8. Gavali K, Karade P. Suitable polymers in floating gastroretentive drug delivery. Int J Scient Res Sci Technol 2020;5:371e82. https://doi.org/10.32628/ijsrst207269.
  9. Khiste R, Bhapkar N, Kulkarni N. A review on applications of hydroxypropylmethylcellulose and natural polymers for the development of modified release drug delivery systems. Res J Pharm Tech 2021;14(2):1163e70. https://doi.org/10.5958/0974-360X.2021.00208.0.
  10. Waghmare SG, Khedekar PB, Aate JR. HPMC based gastro retentive drug delivery system of effervescent guifenesine tablet for dry cough. Electrochem Soc Transac 2022;107:12229e40. https://doi.org/10.1149/10701.12229ecst.
  11. Rahamathulla M, Saisivam S, Alshetaili A, Hani U, Gangadharappa HV, Alshehri MM, et al. Design and evaluation of losartan potassium effervescent floating matrix tablets: in vivo x-ray imaging and pharmacokinetic studies in albino rabbits. Polymers 2021;13:3476. https://doi.org/10.3390/polym13203476.
  12. Patra CN, Priyaa R, Swainb S, Kumar G, Kahnu J, Panigrahia C, et al. Pharmaceutical significance of Eudragit: a review.Future J Pharmaceut Sci 2017;3:33e45.https://doi.org/10.1016/j.fjps.2017.02.001.
  13. Gupta R, Prajapati SK, Pattmaik S, Bhardwaj P.Formulation and evaluation of novel stomach specific floating microspheres bearing famotidine for treatment of gastric ulcer and their radiography study.Asian Pac J Trop Biomed 2014;4:729e35.https://doi.org/10.12980/apjtb.4.201414b73.
  14. Tort SH, Steckl AJ.Self-inflating floating nanofier membranes for controlled drug delivery.Int J Pharm 2020;579:119164.https://doi.org/10.1016/j.ijpharm.2020.119164.
  15. Hegyesi D.Study of the widely used ethylcellulose polymer as film forming and matrix former Ph.D.Thesis.Diana Hegyesi Pharmacist 2016.https://doi.org/10.14232/phd2931.
  16. Ibrahim M, Naguib WY, Sarhan AH, Abdelkader H.Gastroretentive oral drug delivery systems: a promising approach for narrow absorption window drugs.J Adv Biomed Pharm Sci 2019;2:98e111.https://doi.org/10.21608/jabps.2019 .11357 .1042.
  17. El-masry MS, El-Bedaiwy MH, Habib AD. Gastroretentive floating matrix tablets of cefditoren pivoxil: 23 full factorial design, formulation, in vitro evaluation, and optimization. J Appl Pharmaceut Sci 2022;12:116e25. https://doi.org/10.7324/japs.2021.120211.
  18. Kulkarni N, Wakte P, Naik J. Development of floating chitosan-xanthan beads for oral controlled release of glipizide. Int J Pharm Investig 2015;5:73e80. https://doi.org/10.4103/2230-973x.153381.
  19. Hsu Y, Kao C, Ho M, Lee S. To control floating drug delivery system in a simulated gastric environment by adjusting the Shell layer formulation. Biomater Res 2021;25:31. https://doi.org/10.1186/s40824-021-00234-6.
  20. Kanidta Kaewkroek K, Petchsomrit A, Septama WA, Wiwattanapatapee R. Development of starch/chitosan expandable films as a gastroretentive carrier for ginger extract-loaded solid dispersion. Saudi Pharmaceut J 2022;30(2):120e31. https://doi.org/10.1016/j.jsps.2021.12.017.
  21. Bakre GL, Akinyele E, Bamiro O, Adeleye O, Kunle O. Formulation and evaluation of sustained release ibuprofen matrix tablets using starch from maize genotypes as polymer. Acta Marisiensis - Seria Medica 2021;67(2):122e6. https://doi.org/10.2478/amma-2021-0018.
  22. Sabale PV, Gadge GG. Factorial design approach to fabricate and optimize floating tablets based on combination of natural polymer and rice bran wax. Beni-Suef Univ J Basic Appl Sci. 2022;11:5. https://doi.org/10.1186/s43088-021-00186-9.
  23. Lad GC, Gujrathi DS, Mhetre RM, Shrisundar NS. Floating matrix tablet of metformin hydrochloride using natural polymers. Pharm Res (N Y) 2018;8(1):353e79. https://doi.org/10.46624/ajptr.2018.v8.i1.026.
  24. Joshi V, Awasthi R. Floating in-situ raft forming liquid gastroretentive drug delivery system containing poorly watersoluble drug. Bull Pharmaceut Sci Assiut University 2021;44:301e12. https://doi.org/10.21608/bfsa.2021.92498.1156.
  25. Srinivas L, Sagar S. Design, optimization, and evaluation of raft forming gastro retentive drug delivery system of lafutidine using boxebehnken design. Int J Appl Pharm 2022;14:266e74. https://doi.org/10.22159/ijap.2022v14i1.43358.
  26. Palanivelu M, Prashob A, Ramalingam N, Muniyandi KS. Formulation and evaluation of ranitidine hydrochloride loaded floating microspheres for the treatment of gastric ulcer. Int J Curr Sci Res Rev 2021;4:833e45. https://doi.org/10.47191/ijcsrr/v4-i8-01.

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