Conventional dosage forms could not manage release of active substances resulting in reduced bioavailability and side reactions. Being retained in a certain site in the gastrointestinal tract (GIT) could achieve further bioavailability particularly regarding drugs having low gastric absorption and low solubilization or less stability at elevated pH. Therefore, Gastroretentive drug delivery systems (GDDS) are unique approaches with gastric retention and controlling the release rate for maximizing the efficacy. The polymers broadly applied in GDDS are mainly of two sorts, natural and synthetic, according to their nature. Synthetic polymers such as Hydroxypropylmethyl cellulose (HPMC), Eudragit and Ethylcellulose while natural polymers such as natural gums, sodium alginate and Chitosan.


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