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Abstract

A novel substituted 5-chloro-2-benzothiazolemethanamine ligand featuring an imine ‘(-N=CH-) category, 2-((((6-chlorobenzothiazol-2-yl) methyl)imino)methyl)-5-methoxyphenol (CBTMIM), was synthesized through the reaction of 2-benzothiazolemethanamine, 5-chloro, with 2-hydroxy-4-methoxybenzaldehyde in an absolute ethanolic solution. The azomethine ligand and its metal complexes have been identified by using mass spectrometry, 1H and 13C NMR spectroscopy, C, H, N, and S elemental analysis, X-ray diffraction (XRD), (FESEM) microscopy, atomic absorbance spectroscopy. UV-visible spectroscopy, Fourier-transform infrared spectroscopy (FT-IR), magnetic susceptibility, and ionic conductance analysis. The chemical composition and additional measurement data of the metal complexes validate the stoichiometry of the metal: ligand ratio types that include; [M (L)], where is Ag(I) and Au(III) and [(M(L)2], where is Pt(IV) and L is the Azomethen ligand. The data indicate that the tridentate ligand coordinates with silver(I), platinum(IV), and gold(III) ions, confirming the formation of [Ag(CBTMIM)(H2O)], [Au(CBTMIM)Cl2], and [Pt(CBTMIM)2]Cl2 in tetrahedral, square planar, and octahedral geometries, respectively. The ionic conductivities in the DMSO solvent demonstrate the non-electrolytic characteristics of the silver and gold chelates while indicating a 1:2 ionic conductivity for the platinum complex. The ligand and its metal compounds were tested for their ability to inhibit the two human pathogenic bacteria; Staphylococcus aureus and Escherichia coli. In terms of presentation of antimicrobial effectiveness, outcomes show that created new compounds had the ability, adequately. All of the tested compounds illustrated the ability to prevent the bacterial growth found in both Gram + and Gram – bacteria with the relevant essentially with Au(III) and Pt(IV) complexes. In the response of the selected bacteria, we discovered the remarkable biological effects elicited by the ligand and its complexes at 10–3 M Having pathogenic bacterium (Sta. aureus), either with this germ (E. coli), it is a Gram negative bacteria, demonstrated less stimulating effect of the ligand and of their complexes, examined by means of the other type of bacteria.

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